Here is a formal, concise version of your title:

On the Perils of Knowledge: Reflecting on Isaac Asimov’s Insight in the Age of Misinformation

Here is a formal rewrite of the title:

Canada Establishes Academy and Funding Initiative to Counter Russian Disinformation

Here are a few options for a formal rewrite, depending on the specific focus of your content:

Option 1 (Direct and academic):

The Interplay Between Overconfidence and the Dissemination of Misinformation

Option 2 (Comprehensive):

An Analysis of Overconfidence as a Driver of Misinformation

Option 3 (Concise and professional):

Investigating the Relationship Between Overconfidence and Misinformation

Recommendation: If this is for an academic or research-based publication, Option 1 is the most professional and standard choice.